Query 'PCNA, C-terminal domain' matched 21 Records
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Record No : 1 |
| Instance ID | 10249 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | MRVTDFFSQSKRG | | Bait Uniprot Accession | Q9I9A7 | | Bait Uniprot Identifier | CDT1_XENLA | | Bait Gene Name | cdt1 | | Bait Organism | Xenopus laevis (African clawed frog) | | Sequence Position | 4-16 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis | | Interaction ID | 20249 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19595719 | | Comments | Docking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2 |
Record No : 2 |
| Instance ID | 10251 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | PLISDFFAKRKRS | | Bait Uniprot Accession | P49918 | | Bait Uniprot Identifier | CDN1C_HUMAN | | Bait Gene Name | CDKN1C | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 270-282 | | Critical Residues | P5; P7; P9; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20251 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | IMAGe syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 22634751 | | Comments | PIP box motif in human Cyclin-dependent kinase inhibitor p57 (CDKN1C) that is required to bind PCNA |
Record No : 3 |
| Instance ID | 10252 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RRVTDFFARRRP | | Bait Uniprot Accession | Q9H211 | | Bait Uniprot Identifier | CDT1_HUMAN | | Bait Gene Name | CDT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 4-15 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP | | Interaction ID | 20252 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16861906 | | Comments | The human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif |
Record No : 4 |
| Instance ID | 10254 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | TSMTDFYHSKRRL | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 145-157 | | Critical Residues | P10; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP | | Interaction ID | 20254 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18703516, 18794347 | | Comments | PCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis |
Record No : 5 |
| Instance ID | 10256 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RKLTDFYPVRRS | | Bait Uniprot Accession | Q9NQR1 | | Bait Uniprot Identifier | SETD8_HUMAN | | Bait Gene Name | SETD8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 220-231 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay | | Interaction ID | 20256 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20932472, 21220508 | | Comments | CDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase |
Record No : 6 |
| Instance ID | 10258 | | Regular Expression | [NQ]{0,1}xx[ILMV]T[DEN][HMFY][FMY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | NDITNYYKVKRRP | | Bait Uniprot Accession | Q27368 | | Bait Uniprot Identifier | E2F_DROME | | Bait Gene Name | E2f | | Bait Organism | Drosophila melanogaster (Fruit fly) | | Sequence Position | 151-163 | | Critical Residues | P3; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference; Mutation disrupting interaction; Fluorescence-activated cell sorting; Co-IP; Alanine scanning | | Interaction ID | 20258 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19081076 | | Comments | S phase-specific destruction of Drosophila E2f1 is mediated by a PCNA-interacting-protein (PIP) motif in E2f1 |
Record No : 7 |
| Instance ID | 10611 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGTLESFFKR | | Bait Uniprot Accession | P47110 | | Bait Uniprot Identifier | DPOD3_YEAST | | Bait Gene Name | POL32 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 338-347 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20611 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14594808 | | Comments | The C-terminal PCNA binding PIP box motif of POL32, the third subunit of Saccharomyces cerevisiae DNA polymerase delta (Pol delta), that mediates interactions with the carboxyl-terminal region of the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 8 |
| Instance ID | 10612 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QKTLYSFFSP | | Bait Uniprot Accession | P13051 | | Bait Uniprot Identifier | UNG_HUMAN | | Bait Gene Name | UNG | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 4-13 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | SPOT assay; Y2H; ELISA | | Interaction ID | 20612 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10393198 | | Comments | The PCNA binding PIP box motif in human Uracil-DNA glycosylase (UNG) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 9 |
| Instance ID | 10613 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QTTITSHFAK | | Bait Uniprot Accession | P26358 | | Bait Uniprot Identifier | DNMT1_HUMAN | | Bait Gene Name | DNMT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 164-173 | | Critical Residues | P1; P3; P4; P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Competition binding assay; Pull down(GST tag) | | Interaction ID | 20613 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9302295 | | Comments | The PCNA-binding motif in human DNA–(cytosine-5) methyltransferase (MCMT) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA) |
Record No : 10 |
| Instance ID | 10614 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | MQRSIMSFFHP | | Bait Uniprot Accession | P18858 | | Bait Uniprot Identifier | DNLI1_HUMAN | | Bait Gene Name | LIG1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 1-11 | | Critical Residues | P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 20614 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9649448 | | Comments | The PCNA binding PIP box motif in human DNA ligase 1 (LIG1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 11 |
| Instance ID | 10615 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGRLDGFFQV | | Bait Uniprot Accession | P26793 | | Bait Uniprot Identifier | FEN1_YEAST | | Bait Gene Name | RAD27 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 340-349 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20615 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10409728 | | Comments | The PCNA binding PIP box motif in Saccharomyces cerevisiae Flap endonuclease 1 (Fen1/Rad27) that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 12 |
| Instance ID | 10616 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QQTLSSFFMG | | Bait Uniprot Accession | P38766 | | Bait Uniprot Identifier | RRM3_YEAST | | Bait Gene Name | RRM3 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 35-44 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Pull down | | Interaction ID | 20616 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12239216 | | Comments | The PCNA binding PIP box motif in Saccharomyces cerevisiae ATP-dependent DNA helicase RRM3 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 13 |
| Instance ID | 10617 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QATLARFFTS | | Bait Uniprot Accession | P04819 | | Bait Uniprot Identifier | DNLI1_YEAST | | Bait Gene Name | CDC9 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 38-47 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | SPR; Pull down; X-ray crystallography | | Interaction ID | 20617 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17308348 | | Comments | The conserved PCNA interaction motif of Cdc9, yeast DNA ligase I, that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 14 |
| Instance ID | 10618 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QVSITGFFQR | | Bait Uniprot Accession | Q15054 | | Bait Uniprot Identifier | DPOD3_HUMAN | | Bait Gene Name | POLD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 456-465 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20618 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15576034 | | Comments | The PCNA binding PIP box motif in human DNA polymerase delta subunit 3 (POLD3) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 15 |
| Instance ID | 10619 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QLRIDSFFRL | | Bait Uniprot Accession | P28715 | | Bait Uniprot Identifier | ERCC5_HUMAN | | Bait Gene Name | ERCC5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 990-999 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Competition binding assay; Pull down(GST tag) | | Interaction ID | 20619 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9305916 | | Comments | The PCNA binding PIP box motif in human DNA excision repair protein ERCC-5, a structure-specific endonuclease involved in DNA replication, that mediates its interaction with Proliferating cell nuclear antigen (PCNA) |
Record No : 16 |
| Instance ID | 10620 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QTSMTDFYHS | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 144-153 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20620 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8861913 | | Comments | The C-terminal PCNA binding PIP box motif of human Cyclin-dependent kinase inhibitor 1 (CDKN1A/p21/WAF1/CIP1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 17 |
| Instance ID | 10621 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QTTIEDFFGT | | Bait Uniprot Accession | P12887 | | Bait Uniprot Identifier | UNG_YEAST | | Bait Gene Name | UNG1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 21-30 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20621 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12239216 | | Comments | The predicted PCNA binding PIP box motif in Saccharomyces cerevisiae Uracil-DNA glycosylase (UNG1) that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 18 |
| Instance ID | 10622 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QKSIMSFFGK | | Bait Uniprot Accession | P30261 | | Bait Uniprot Identifier | DPOD3_SCHPO | | Bait Gene Name | cdc27 | | Bait Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | | Sequence Position | 362-371 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag); Western blot | | Interaction ID | 20622 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10698951 | | Comments | Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal PCNA binding PIP box motif |
Record No : 19 |
| Instance ID | 10623 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QSSLLSFFSK | | Bait Uniprot Accession | Q03834 | | Bait Uniprot Identifier | MSH6_YEAST | | Bait Gene Name | MSH6 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 27-36 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20623 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11062484 | | Comments | The N-terminal PCNA binding PIP box motif of Saccharomyces cerevisiae DNA mismatch repair protein MSH6 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 20 |
| Instance ID | 10624 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGRLDDFFKV | | Bait Uniprot Accession | P39748 | | Bait Uniprot Identifier | FEN1_HUMAN | | Bait Gene Name | FEN1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 337-346 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Peptide mapping; Y2H; Co-IP; Competition binding assay | | Interaction ID | 20624 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15576034, 9178907 | | Comments | The PCNA binding PIP box motif in human Flap endonuclease 1 (FEN1)/ DNase IV that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 21 |
| Instance ID | 10625 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QKRINEFFPR | | Bait Uniprot Accession | P07276 | | Bait Uniprot Identifier | RAD2_YEAST | | Bait Gene Name | RAD2 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 995-1004 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20625 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11545742 | | Comments | The predicted PCNA binding PIP box motif in Saccharomyces cerevisiae DNA polymerase (Pol) eta/ DNA repair protein RAD2 that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30), which is essential for the in vivo function of Poleta |
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